Development of a high-affinity ligand that binds irreversibly to Mel1b melatonin receptors

J Med Chem. 1997 Dec 19;40(26):4195-8. doi: 10.1021/jm970437q.

Authors

P A Witt-Enderby¹, G H Chu, M L Gillen, P K Li

Affiliation

¹ Department of Pharmacology and Toxicology, School of Pharmacy, Duquesne University, Pittsburgh, Pennsylvania 15282, USA. wittp@duq3.cc.duq.edu

PMID: 9435890
DOI: 10.1021/jm970437q

No abstract available

MeSH terms

Affinity Labels / chemical synthesis*
Affinity Labels / metabolism
Affinity Labels / pharmacology
Alkylating Agents / chemical synthesis*
Alkylating Agents / metabolism
Alkylation
Amides / chemical synthesis*
Amides / metabolism
Animals
CHO Cells
Cricetinae
Drug Design
Ligands
Molecular Structure
Naphthalenes / chemical synthesis*
Naphthalenes / metabolism
Protein Binding
Receptors, Cell Surface / classification
Receptors, Cell Surface / metabolism*
Receptors, Cytoplasmic and Nuclear / classification
Receptors, Cytoplasmic and Nuclear / metabolism*
Receptors, Melatonin

Substances

Affinity Labels
Alkylating Agents
Amides
Ligands
N-(2-(2-(bromoacetoxy)-7-methoxynaphtyl)ethyl)-propionamide
Naphthalenes
Receptors, Cell Surface
Receptors, Cytoplasmic and Nuclear
Receptors, Melatonin